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Am J Psychiatry. 2005 Mar;162(3):606-8.

A three-dimensional morphometric study of craniofacial shape in schizophrenia.

Author information

  • 1Department of Psychiatry and Health Behavior, Medical College of Georgia, 1515 Pope Ave., Augusta, GA 30912-3800, USA. pbuckley@mail.mcg.edu

Abstract

BACKGROUND:

Subtle dysmorphogenesis of the craniofacial region constitutes important corroborating evidence of the neurodevelopmental origins of schizophrenia. Advances in facial visualization now allow for three-dimensional anthropometric evaluations of potentially greater discriminatory power in examining the complex geometric relationships of facial topography.

METHOD:

Sixty-five anthropometrically derived landmarks were identified from three-dimensional facial images collected from 14 patients with schizophrenia and 11 comparison subjects, imaged with a high-resolution, portable laser scanner.

RESULTS:

Using the Procrustes morphometric approach for shape analysis, the difference in mean shapes was highly significant, with patients exhibiting superoinferior elongation of the face.

CONCLUSIONS:

The topography of craniofacial anomalies in schizophrenia is not random and points to midline deformation.

PMID:
15741481
[PubMed - indexed for MEDLINE]
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