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Psychiatry Res. 2005 Feb 28;133(2-3):273-6.

Clozapine: weight gain in a pair of monozygotic twins concordant for schizophrenia and mild mental retardation.

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  • 1Department of Child and Adolescent Psychiatry, Philipps-University, Hans-Sachs-Str. 4-8, 35033 Marburg, Germany.


Clozapine is an atypical antipsychotic known to cause considerable weight gain. The extent to which genetic factors determine weight gain is unknown. Here we report on a pair of female monozygotic twins concordant for schizophrenia and mild mental retardation who were treated with clozapine over 5.5 years. One twin gained a total of 53.1 kg and had a weight of 107.5 kg (BMI=38.1 kg/m2) at the end of the observation period. The other twin gained a total of 48.2 kg and finally had a weight of 100.4 kg (BMI=33.8 kg/m2). Because both patients experienced considerable weight gain during treatment, our observation suggests that the antipsychotic-induced weight gain is under strong genetic control.

[PubMed - indexed for MEDLINE]
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