Hautarzt. 2005 Sep;56(9):860-5.

[Antimicrobial peptides. A perspective for the treatment of chronic wounds?].

[Article in German]

Source

Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen.

Abstract

Human antimicrobial peptides play a substantial role in the immune response to various dermatological diseases, such as acne, atopic dermatitis and psoriasis vulgaris, and even mucosal HIV-protection is mediated inter alia by antimicrobial peptides. In wound healing, the antimicrobial and immune-modulating properties of, in particular, human defensins and cathelicidins can affect important controlling factors. For example, the interaction between different antimicrobial peptides and growth factors supports neoangiogenesis. Although further clinical investigations are necessary to identify the exact effects of antimicrobial peptides in chronic wounds, such peptides could be a promising therapeutic option in the near future for the treatment of patients with chronic wounds by promoting endogen expression or exogenous supplementation.

PMID:: 15735893; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

English Abstract

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Skin Infections - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review Biology and clinical relevance of naturally occurring antimicrobial peptides. [J Allergy Clin Immunol. 2002]
Review Biology and clinical relevance of naturally occurring antimicrobial peptides.
Gallo RL, Murakami M, Ohtake T, Zaiou M. J Allergy Clin Immunol. 2002 Dec; 110(6):823-31.
Review Antimicrobial peptides. [J Am Acad Dermatol. 2005]
Review Antimicrobial peptides.
Izadpanah A, Gallo RL. J Am Acad Dermatol. 2005 Mar; 52(3 Pt 1):381-90; quiz 391-2.
Review [Effector molecules of the innate immune system for treatment of wound infections]. [Chirurg. 2007]
Review [Effector molecules of the innate immune system for treatment of wound infections].
Steinsträsser L, Langer S, Lehnhardt M, Steinau HU. Chirurg. 2007 Apr; 78(4):343-8.
Potential therapeutic application of host defense peptides. [Methods Mol Biol. 2010]
Potential therapeutic application of host defense peptides.
Zhang L, Falla TJ. Methods Mol Biol. 2010; 618:303-27.
Review Susceptibility of periodontopathogenic and cariogenic bacteria to defensins and potential therapeutic use of defensins in oral diseases. [Curr Pharm Des. 2007]
Review Susceptibility of periodontopathogenic and cariogenic bacteria to defensins and potential therapeutic use of defensins in oral diseases.
Komatsuzawa H, Ouhara K, Kawai T, Yamada S, Fujiwara T, Shiba H, Kurihara H, Taubman MA, Sugai M. Curr Pharm Des. 2007; 13(30):3084-95.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

[Antimicrobial peptides. A perspective for the treatment of chronic wounds?].
[Antimicrobial peptides. A perspective for the treatment of chronic wounds?].
Hautarzt. 2005 Sep ;56(9):860-5.

PubMed
The alkylating carcinogen N-methyl-N'-nitro-N-nitrosoguanidine activates the pla...
The alkylating carcinogen N-methyl-N'-nitro-N-nitrosoguanidine activates the plasminogen activator inhibitor-1 gene through sequential phosphorylation of p53 by ATM and ATR kinases.
Thromb Haemost. 2005 Mar ;93(3):584-91.

PubMed
TRAIL is a key target in S-phase slowing-dependent apoptosis induced by interfer...
TRAIL is a key target in S-phase slowing-dependent apoptosis induced by interferon-beta in cervical carcinoma cells.
Oncogene. 2005 Apr 7 ;24(15):2536-46.

PubMed
Retinoic acid stabilizes p27Kip1 in EBV-immortalized lymphoblastoid B cell lines...
Retinoic acid stabilizes p27Kip1 in EBV-immortalized lymphoblastoid B cell lines through enhanced proteasome-dependent degradation of the p45Skp2 and Cks1 proteins.
Oncogene. 2005 Apr 7 ;24(15):2483-94.

PubMed
Spatial processing within the mustache bat echolocation system: possible mechani...
Spatial processing within the mustache bat echolocation system: possible mechanisms for optimization.
J Comp Physiol A. 1992 Jan ;170(1):57-71.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: