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    Oncogene. 2005 Apr 21;24(18):3063-6.

    Mutation frequencies and AID activation state in B-cell lymphomas from Ung-deficient mice.

    Nilsen H, An Q, Lindahl T.

    Source

    Clare Hall Laboratories, CR-UK London Research Institute, South Mimms, Hertfordshire EN6 3LD, UK.

    Abstract

    B-cell lymphomas arising in lymph nodes and spleen of aging mice deficient in the Ung DNA glycosylase were recovered, dispersed, grown in short-term culture, and CD19-positive B-cells retrieved and analysed. Several tumors as well as controls only expressed detectable amounts of the Aid deaminase after mitogenic stimulation, as estimated by real-time PCR of transcripts. However, one unusually large lymph node tumor expressed a high level of Aid constitutively. This particular tumor also showed a substantially increased mutation frequency in the Aid gene itself as well as in the bcl-6 and c-myc genes, but not in the p53 gene, consistent with aberrant somatic hypermutation. Other B-cell lymphomas from Ung(-/-) mice exhibited a modest increase in mutation frequency.

    PMID:
    15735713
    [PubMed - indexed for MEDLINE]

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