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Tob Control. 2005 Feb;14(1):49-54.

A prospective study of off-label use of, abuse of, and dependence on nicotine inhaler.

Author information

  • 1Department of Psychiatry, Psychology & Family Practice, University of Vermont, 38 Fletcher Place, Burlington, VT 05401-1419, USA. john.hughes@uvm.edu

Abstract

OBJECTIVE:

To determine the incidence of off-label use of, abuse of, and dependence on prescription nicotine inhaler.

DESIGN:

Prospective telephone and internet interviews for six months.

PARTICIPANTS:

535 new inhaler users.

MAIN OUTCOME:

Structured interview about off-label use (that is, use of inhaler for non-cessation reasons or concurrent use of inhaler and cigarettes) and Diagnostic and statistical manual, fourth edition (DSM-IV) and International classification of diseases, 10th edition (ICD-10) criteria for abuse and dependence

RESULTS:

Although many used inhaler and cigarettes concurrently at some time (43-55%), few used inhaler for non-cessation reasons (4-9%) and few persisted in off label use (8-16%; 95% confidence interval (CI) 5% to 19%). No participant met ICD-10 criteria for harmful use/abuse (95% CI 0% to 3.3%). Eight subjects (1.4%) appeared to meet DSM-IV or ICD-10 criteria for dependence on inhaler, but none were found dependent in a clinical expert interview (95% CI 0% to 3.3%).

CONCLUSIONS:

Although transient concurrent use of inhaler and cigarettes often occurs, use for non-cessation reasons, abuse and dependence are rare.

PMID:
15735300
[PubMed - indexed for MEDLINE]
PMCID:
PMC1747971
Free PMC Article
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