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Lancet. 2005 Feb 26-Mar 4;365(9461):730-1.
Risk of oral infection with bovine spongiform encephalopathy agent in primates.
Lasmézas CI,
Comoy E,
Hawkins S,
Herzog C,
Mouthon F,
Konold T,
Auvré F,
Correia E,
Lescoutra-Etchegaray N,
Salès N,
Wells G,
Brown P,
Deslys JP.
Commissariat à l'Energie Atomique/Direction des Sciences du Vivant/Départment de Recherche Médicale, 18 Route du Panorama, 92265 Fontenay-aux-Roses, France.
The uncertain extent of human exposure to bovine spongiform encephalopathy (BSE)--which can lead to variant Creutzfeldt-Jakob disease (vCJD)--is compounded by incomplete knowledge about the efficiency of oral infection and the magnitude of any bovine-to-human biological barrier to transmission. We therefore investigated oral transmission of BSE to non-human primates. We gave two macaques a 5 g oral dose of brain homogenate from a BSE-infected cow. One macaque developed vCJD-like neurological disease 60 months after exposure, whereas the other remained free of disease at 76 months. On the basis of these findings and data from other studies, we made a preliminary estimate of the food exposure risk for man, which provides additional assurance that existing public health measures can prevent transmission of BSE to man.
PMID: 15733719 [PubMed - indexed for MEDLINE]
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