J Child Neurol. 1992 Apr;7(2):142-55.

Medulloblastoma: I. Clinical, diagnostic, and therapeutic overview.

Tomlinson FH, Scheithauer BW, Meyer FB, Smithson WA, Shaw EG, Miller GM, Groover RV.

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Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905.

Abstract

Medulloblastoma, the most common embryonal tumor of the central nervous system, affects both children and adults. It poses a significant therapeutic challenge in that age-dependent differences exist, not only in their pathobiology, but in the efficacy of chemotherapy and radiotherapy. This is particularly the case in very young children, whose still developing nervous system exhibits a low tolerance to radiotherapy. We review the epidemiology, clinical presentation, radiologic features, and current therapeutic concepts relative to this unique neoplasm. Efforts are made to highlight clinical controversies.

PMID:: 1573231; [PubMed - indexed for MEDLINE]

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