Abstract
Malettinins B-D (2-4), three new antimicrobial polyketide-derived metabolites related to the previously reported malettinin A (1), have been obtained from nonsporulating cultures of an isolate of Mycelia sterilia MYC-155 (= NRRL 29110) collected from colonies of Hypoxylon stromata. Malettinins B (2) and C (3) are partially reduced analogues of malettinin A and were identified by analysis of NMR and MS data. Malettinin D (4) is biogenetically similar, but possesses a new ring system, and the structure of 4 was established by single-crystal X-ray diffraction analysis.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Agaricales / chemistry*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Bacillus subtilis / drug effects
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Candida albicans / drug effects
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Crystallography, X-Ray
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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Molecular Structure
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New Mexico
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Nuclear Magnetic Resonance, Biomolecular
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification*
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Spiro Compounds / pharmacology
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Furans
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Spiro Compounds
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malettinin B
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malettinin C
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malettinin D