Antimicrob Agents Chemother. 2005 Mar;49(3):1229-31.

Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-Beijing strains isolated from patients in Germany.

Hillemann D, Kubica T, Rüsch-Gerdes S, Niemann S.

Source

National Reference Center for Mycobacteria, Forschungszentrum Borstel, Borstel, Germany. dhillemann@fz-borstel.de

Abstract

Genotypic analysis of 103 multidrug-resistant Mycobacterium tuberculosis strains isolated in Germany in 2001 revealed that mutations in codon 531 (75.7%) of the rpoB gene and codon 315 (88.4%) of the katG gene are most frequent. Beijing genotype strains (60.2% of all isolates) displayed a different distribution of resistance mutations than non-Beijing strains.

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Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-Beijing strains isolated from patients in Germany.

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