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Neurology. 2005 Feb 22;64(4):670-4.

"Off" gait freezing and temporal discrimination threshold in patients with Parkinson disease.

Author information

  • 1Department of Neurology, Youngdong Severance Hospital, 146-92 Dogok-dong, Kangnam-gu, Seoul, Korea. myungs56@yumc.yonsei.ac.kr

Abstract

OBJECTIVE:

To investigate the relationship between temporal discrimination threshold (TDT) and "off" period gait freezing (OGF) in patients with fluctuating Parkinson disease (PD).

METHODS:

TDT values were measured at the dorsum of the toes in 11 control subjects and 22 patients with PD with a wearing-off phenomenon (16 patients with OGF and 6 patients without OGF).

RESULTS:

During the l-dopa "off" period, TDT values increased abnormally in both patient groups but were significantly higher in patients with OGF than in those without OGF. A positive correlation was found between the severity of OGF and TDT values measured by different point stimulation. In patients with OGF, a single dose of l-dopa treatment normalized TDT values and ameliorated OGF.

CONCLUSIONS:

Dopa-responsive abnormal discriminative sensory processing may be a possible cause of "off" period gait freezing observed in patients with fluctuating Parkinson disease.

PMID:
15728290
[PubMed - indexed for MEDLINE]
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