Genomics. 1992 Apr;12(4):833-5.

FRA2B is distinct from inverted telomere repeat arrays at 2q13.

IJdo JW, Baldini A, Wells RA, Ward DC, Reeders ST.

Source

Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510.

Abstract

Human chromosome 2 was formed by a telomere-to-telomere fusion of two ancestral ape chromosomes. The fusion point is localized in chromosomal band 2q13, which also contains the rare, folate-sensitive fragile site FRA2B. It has been hypothesized that this fragile site may be related to the presence of interstitial telomeric and subtelomeric sequences, which have come to lie in an inverted repeat arrangement as a result of the fusion event. Fluorescence in situ hybridization of a genomic cosmid c8.1, which spans the fusion point, was carried out on metaphase spreads of an individual who expressed the fragile site at 2q13. We show that the fusion point maps distal to this fragile site. Therefore, we conclude that the inverted arrays of telomeric and subtelomeric sequences found at this fusion point are unlikely to correspond to the rare fragile site at 2q13.

PMID:: 1572659; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

DNA Probes

LinkOut - more resources

Full Text Sources

Elsevier Science

Supplemental Content

Save items

Related citations in PubMed

Origin of human chromosome 2: an ancestral telomere-telomere fusion. [Proc Natl Acad Sci U S A. 1991]
Origin of human chromosome 2: an ancestral telomere-telomere fusion.
IJdo JW, Baldini A, Ward DC, Reeders ST, Wells RA. Proc Natl Acad Sci U S A. 1991 Oct 15; 88(20):9051-5.
Fragile site and interstitial telomere repeat sequences at the fusion point of a de novo (Y;13) translocation. [Hum Genet. 1996]
Fragile site and interstitial telomere repeat sequences at the fusion point of a de novo (Y;13) translocation.
Boutouil M, Fetni R, Qu J, Dallaire L, Richer CL, Lemieux N. Hum Genet. 1996 Sep; 98(3):323-7.
Murine radiation myeloid leukaemogenesis: relationship between interstitial telomere-like sequences and chromosome 2 fragile sites. [Genes Chromosomes Cancer. 1993]
Murine radiation myeloid leukaemogenesis: relationship between interstitial telomere-like sequences and chromosome 2 fragile sites.
Bouffler S, Silver A, Papworth D, Coates J, Cox R. Genes Chromosomes Cancer. 1993 Feb; 6(2):98-106.
Review Human chromosome fragility. [Biochim Biophys Acta. 2008]
Review Human chromosome fragility.
Lukusa T, Fryns JP. Biochim Biophys Acta. 2008 Jan; 1779(1):3-16. Epub 2007 Dec 3.
Review The molecular basis of fragile sites in human chromosomes. [Curr Opin Genet Dev. 1995]
Review The molecular basis of fragile sites in human chromosomes.
Sutherland GR, Richards RI. Curr Opin Genet Dev. 1995 Jun; 5(3):323-7.

See reviews... See all...

Cited by 1 PubMed Central article

Genomic structure and evolution of the ancestral chromosome fusion site in 2q13-2q14.1 and paralogous regions on other human chromosomes. [Genome Res. 2002]
Genomic structure and evolution of the ancestral chromosome fusion site in 2q13-2q14.1 and paralogous regions on other human chromosomes.
Fan Y, Linardopoulou E, Friedman C, Williams E, Trask BJ. Genome Res. 2002 Nov; 12(11):1651-62.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

FRA2B is distinct from inverted telomere repeat arrays at 2q13.
FRA2B is distinct from inverted telomere repeat arrays at 2q13.
Genomics. 1992 Apr ;12(4):833-5.

PubMed
Polymorphisms in the human glucocerebrosidase gene.
Polymorphisms in the human glucocerebrosidase gene.
Genomics. 1992 Apr ;12(4):795-800.

PubMed
Intratumoral molecular or genetic markers as predictors of clinical outcome with...
Intratumoral molecular or genetic markers as predictors of clinical outcome with chemotherapy in colorectal cancer.
Semin Oncol. 2005 Feb ;32(1):120-7.

PubMed
Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsoni...
Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations.
Am J Hum Genet. 2005 Apr ;76(4):672-80. Epub 2005 Feb 22 .

PubMed
[Risk-benefit evaluation of medicinal products. An element of Health Technology ...
[Risk-benefit evaluation of medicinal products. An element of Health Technology Assessment].
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2005 Feb ;48(2):204-14.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: