Display Settings:

Format

Send to:

Choose Destination
Arch Surg. 2005 Feb;140(2):174-82.

Use of antimicrobial prophylaxis for major surgery: baseline results from the National Surgical Infection Prevention Project.

Author information

  • 1Oklahoma Foundation for Medical Quality, Inc, Oklahoma City, OK 73134-2627, USA. dbratzler@okqio.sdps.org

Abstract

HYPOTHESIS:

Surgical site infections (SSIs) are a major contributor to patient injury, mortality, and health care costs. Despite evidence of effectiveness of antimicrobials to prevent SSIs, previous studies have demonstrated inappropriate timing, selection, and excess duration of administration of antimicrobial prophylaxis. We herein describe the use of antimicrobial prophylaxis for Medicare patients undergoing major surgery.

DESIGN:

National retrospective cohort study with medical record review.

SETTING:

Two thousand nine hundred sixty-five acute-care US hospitals.

PATIENTS:

A systematic random sample of 34,133 Medicare inpatients undergoing coronary artery bypass grafting; other open-chest cardiac surgery (excluding transplantation); vascular surgery, including aneurysm repair, thromboendarterectomy, and vein bypass operations; general abdominal colorectal surgery; hip and knee total joint arthroplasty (excluding revision surgery); and abdominal and vaginal hysterectomy from January 1 through November 30, 2001.

MAIN OUTCOME MEASURES:

The proportion of patients who had parenteral antimicrobial prophylaxis initiated within 1 hour before the surgical incision; the proportion of patients who were given a prophylactic antimicrobial agent that was consistent with currently published guidelines; and the proportion of patients whose antimicrobial prophylaxis was discontinued within 24 hours after surgery.

RESULTS:

An antimicrobial dose was administered to 55.7% (95% confidence interval [CI], 54.8%-56.6%) of patients within 1 hour before incision. Antimicrobial agents consistent with published guidelines were administered to 92.6% (95% CI, 92.3%-92.8%) of the patients. Antimicrobial prophylaxis was discontinued within 24 hours of surgery end time for only 40.7% (95% CI, 40.2%-41.2%) of patients.

CONCLUSION:

Substantial opportunities exist to improve the use of prophylactic antimicrobials for patients undergoing major surgery.

Comment in

PMID:
15724000
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk