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    Psychiatr Genet. 2005 Mar;15(1):67-9.

    Serotonin 2A receptor gene polymorphism and personality traits: no evidence for significant association.

    Tochigi M, Umekage T, Kato C, Marui T, Otowa T, Hibino H, Otani T, Kohda K, Kato N, Sasaki T.

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    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Japan.

    Abstract

    A number of studies have observed associations between the serotonin 2A (5-HT2A) receptor and mental disorders. Here, we investigated correlations between polymorphisms (-1438G/A and 102T/C) of the 5-HT2A gene and personality traits in healthy Japanese volunteers (n = 239). The personality traits were evaluated using the Revised NEO Personality Inventory (NEO PI-R). The -1438G/A and 102T/C were in complete linkage disequilibrium. There was a tendency for associations between the genotype and the scores for Agreeableness, Conscientiousness and Neuroticism of the NEO PI-R (P = 0.028, 0.039 and 0.062, respectively; analysis of variance, uncorrected for multiple testing). Subjects with the A/A of -1438G/A (or T/T of 102T/C) appeared to be lower in Neuroticism and higher in Conscientiousness than the rest of the subjects. However, the results were statistically non-significant after Bonferroni's correction for multiple testing of the five scales of the NEO PI-R. Thus, the present study provided no evidence for statistically significant associations between the 5-HT2A polymorphisms and the personality traits.

    PMID:
    15722960
    [PubMed - indexed for MEDLINE]

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