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Curr Opin Neurobiol. 2005 Feb;15(1):67-72.

Growth of dendritic spines: a continuing story.

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  • 1Friedrich Miescher Institute, Maulbeerstrasse 66, 4058 Basel, Switzerland.


Dendritic spines, which are present at the vast majority of excitatory synapses in the central nervous system, have a specialized cytoskeleton of dynamic actin filaments that makes them capable of rapid morphological plasticity. During development, structural remodeling of nascent spines is an important factor in experience-dependent shaping of neuronal circuits, whereas in the adult brain spines maintain a balance between morphological stability and plasticity.

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