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Mol Cell. 2005 Feb 18;17(4):472-3.

OS-9: another piece in the HIF complex story.

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  • 1The Chemistry Research laboratory, Oxford University, Mansfield Road, Oxford OX1 3TA, United Kingdom.


In this issue of Molecular Cell, the Semenza group reports that OS-9, a common protein of unassigned function, promotes the O2-dependent degradation of hypoxia inducible factor (HIF) via binding to both HIF and the HIF prolyl-hydroxylases, implying that OS-9 is part of a multiprotein complex involved in the hypoxic response (Baek et al., 2005).

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