Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Hematol Rep. 2005 Mar;4(2):145-8.

Thrombocytopenia in dengue fever.

Author information

  • 1Medical Corps, US Navy, Department of Laboratory Medicine, Georgetown University Hospital, 3800 Reservoir Road, Room 1321, Washington, DC 20007, USA.

Abstract

Dengue is probably the most important arthropod-borne viral disease in terms of human morbidity and mortality. We review the pathophysiology of thrombocytopenia and clinical bleeding in dengue across the spectrum of disease. The mechanisms of thrombocytopenia and coagulopathy are complex, involving platelet activation, procoagulant and anticoagulant arms of the coagulation system, complement, cytokines, and endothelial cells. Platelet counts do not correlate well with clinical bleeding. Although serious bleeding is rare, patients should be monitored closely for hemorrhagic manifestations and thrombocytopenia. Symptomatic thrombocytopenia may require platelet transfusion.

PMID:
15720964
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk