Histopathology. 2005 Mar;46(3):334-41.

Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying FUS-CHOP transcript.

De Cecco L, Gariboldi M, Reid JF, Lagonigro MS, Tamborini E, Albertini V, Staurengo S, Pilotti S, Pierotti MA.

Source

FIRC Institute for Molecular Oncology Foundation, IFOM, Milano, Italy.

Abstract

AIMS:

To describe a tumour with morphological and immunophenotypic characteristics of epithelioid variant of pleomorphic liposarcoma. Pleomorphic liposarcoma is a very rare variant of liposarcoma defined morphologically by the presence of pleomorphic lipoblasts showing peculiar epithelial-like features that can be confused with primary or metastatic carcinoma.

METHODS AND RESULTS:

Molecular analysis demonstrated for the first time the presence of FUS-CHOP transcript in this liposarcoma variant. Microarray analysis revealed a gene expression profile related to a more aggressive tumour type when compared with other myxoid/round cell liposarcomas.

CONCLUSIONS:

The present data show that the epithelioid variant of pleomorphic liposarcoma represents a further variant of myxoid liposarcoma sharing the FUS-CHOP fusion transcript but carrying a distinct expression profile, in keeping with its aggressive clinical course.

PMID:: 15720420; [PubMed - indexed for MEDLINE]

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