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Chem Commun (Camb). 2005 Feb 28;(8):996-8. Epub 2005 Jan 10.

Cationic polyhedral oligomeric silsesquioxane (POSS) units as carriers for drug delivery processes.

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  • 1Department of Chemistry, The University of Massachusetts, Amherst, MA 01003, USA.


Quaternary ammonium functionalized polyhedral oligomeric silsesquioxane (OctaAmmonium-POSS) units, widely employed as additives in ceramic and polymeric systems, possess many attributes which make them attractive as biocompatible drug carriers: nanoscale size, three-dimensional functionality, efficient cellular uptake, low toxicity, and high solubility.

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