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Minerva Gastroenterol Dietol. 2004 Mar;50(1):97-101.

[Need for hospital admission in patients with ulcerative colitis during maintenance with azathioprine].

[Article in Italian]

Author information

  • 1Day Hospital, Divisione di Gastroenterologia e Nutrizione Clinica, Ospedale Molinette, Turin, Italy.

Abstract

AIM:

The aim of this study is to analyse the clinical course of ulcerative colitis during maintenance therapy with azathioprine, a drug which is still not proved to be able to modify the natural history of the disease.

METHODS:

A retrospective study is made of data regarding the frequency of hospital admission for patients with ulcerative colitis referring to a gastroenterological Day-Hospital between 1991 and 2000. The disease history of these patients has been divided into 2 sections: one preceding and the other following an index-event, identified as the beginning of a maintenance regimen with azathioprine; this allowed to find possible differences in the clinical course after the index-event. Patients were controls of themselves.

RESULTS:

Seventeen patients qualified for analysis. Remission from an acute severe attack of ulcerative colitis was reached by intravenous or oral cyclosporine for 14 of them and by prednisone for 3 of them. The maintenance treatment with azathioprine, which started in all but 1 patient (intention-to-treat), showed a reduction in the number of hospital admissions, decreasing from a mean of 2.12+/-0.69 in the preceding 4.2+/-4.3 years to a mean of 0.12+/-0.33 in the following 5.8+/-2.5 years (p=0.000).

CONCLUSIONS:

Patients undergoing maintenance therapy with azathioprine showed face fewer relapses needing hospitalisation than those without azathioprine.

PMID:
15719011
[PubMed - indexed for MEDLINE]
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