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    Science. 2005 Feb 18;307(5712):1121-4.

    Flexible control of mutual inhibition: a neural model of two-interval discrimination.

    Source

    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

    Abstract

    Networks adapt to environmental demands by switching between distinct dynamical behaviors. The activity of frontal-lobe neurons during two-interval discrimination tasks is an example of these adaptable dynamics. Subjects first perceive a stimulus, then hold it in working memory, and finally make a decision by comparing it with a second stimulus. We present a simple mutual-inhibition network model that captures all three task phases within a single framework. The model integrates both working memory and decision making because its dynamical properties are easily controlled without changing its connectivity. Mutual inhibition between nonlinear units is a useful design motif for networks that must display multiple behaviors.

    Comment in

    • Neuroscience. Adaptive coding. [Science. 2005]
    PMID:
    15718474
    [PubMed - indexed for MEDLINE]
    Free full text

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