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Science. 2005 Feb 18;307(5712):1118-21.

Learned predictions of error likelihood in the anterior cingulate cortex.

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  • 1Department of Psychology, CB 1125, Washington University, St. Louis, MO 63130, USA. jwbrown@artsci.wustl.edu


The anterior cingulate cortex (ACC) and the related medial wall play a critical role in recruiting cognitive control. Although ACC exhibits selective error and conflict responses, it has been unclear how these develop and become context-specific. With use of a modified stop-signal task, we show from integrated computational neural modeling and neuroimaging studies that ACC learns to predict error likelihood in a given context, even for trials in which there is no error or response conflict. These results support a more general error-likelihood theory of ACC function based on reinforcement learning, of which conflict and error detection are special cases.

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  • Neuroscience. Adaptive coding. [Science. 2005]
[PubMed - indexed for MEDLINE]
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