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1: Med Immunol. 2005 Feb 17;4(1):1.Click here to read Click here to read Links

FADD adaptor in cancer.

Tourneur L, Buzyn A, Chiocchia G.

Département d'Immunologie, Institut Cochin, INSERM U 567, CNRS UMR 8104, IFR 116, Université René Descartes, Paris V, Paris, France. chiocchia@cochin.inserm.fr.

FADD (Fas Associated protein with Death Domain) is a key adaptor molecule transmitting the death signal mediated by death receptors. In addition, this multiple functional protein is implicated in survival/proliferation and cell cycle progression. FADD functions are regulated via cellular sublocalization, protein phosphorylation, and inhibitory molecules. In the present review, we focus on the role of the FADD adaptor in cancer. Increasing evidence shows that defects in FADD protein expression are associated with tumor progression both in mice and humans. Better knowledge of the mechanisms leading to regulation of FADD functions will improve understanding of tumor growth and the immune escape mechanisms, and could open a new field for therapeutic interventions.

PMID: 15717929 [PubMed - as supplied by publisher]

PMCID: PMC550674

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