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Nat Rev Genet. 2005 Feb;6(2):151-7.

Conserved non-genic sequences - an unexpected feature of mammalian genomes.

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  • 1Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. md4@sanger.ac.uk

Abstract

Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?

PMID:
15716910
[PubMed - indexed for MEDLINE]
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