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Transplantation. 2005 Jan 15;79(1):116-8.

Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture system.

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  • 1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.

Abstract

BACKGROUND:

Cidofovir and Leflunomide are used empirically in the treatment of BK virus nephropathy. The aim of this study is to quantify the antiviral activity of these drugs.

METHODS:

BK virus was grown in a cell-culture system. The rate of viral replication in the presence or absence of the drug being tested was assessed using a quantitative polymerase chain reaction assay.

RESULTS:

The inhibitory concentration, effective concentration, and selectivity index for Leflunomide are 39.7+/-6.9, 11.3+/-2.8, and 3.8+/-0.8 microg/mL, respectively. For Cidofovir, these indices were, respectively, 63.9+/-17.2, 36.3+/-11.7, and 2.3+/-0.8 microg/mL.

CONCLUSIONS:

The in vitro activity of Cidofovir and Leflunomide is modest, and the selectivity index is low. There is a need to develop more effective and less toxic anti-BK virus drugs for clinical use.

PMID:
15714178
[PubMed - indexed for MEDLINE]
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