J Am Chem Soc. 2005 Feb 23;127(7):2044-5.

Protein heterodimerization through ligand-bridged multivalent pre-organization: enhancing ligand binding toward both protein targets.

Liu J, Zhang Z, Tan X, Hol WG, Verlinde CL, Fan E.

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Biomolecular Structure Center, Department of Chemistry, University of Washington, Seattle, Washington 98195, USA.

Abstract

Structure-based design of a bifunctional ligand for two protein pentamers, cholera toxin B pentamer (CTB) and human serum amyloid P component (SAP), leads to multivalent dimerization of CTB and SAP in solution. This multivalent heterodimerization of proteins significantly enhances the affinity of the bifunctional ligand toward both target proteins.

PMID:: 15713072; [PubMed - indexed for MEDLINE]

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