Curr Opin Gastroenterol. 2005 Mar;21(2):223-7.

Vitamin E regulation.

Source

Linus Pauling Institute, Oregon State University Corvallis, Oregon 97331, USA. maret.traber@oregonstate.edu

Abstract

PURPOSE OF REVIEW:

Vitamin E deficiency in humans has lead to the discovery of regulatory mechanisms that control plasma alpha-tocopherol concentrations and prevent the accumulation of other molecules with vitamin E-antioxidant activity, such as gamma-tocopherol. This review describes these regulatory mechanisms.

RECENT FINDINGS:

alpha-tocopherol regulatory proteins have been cloned and crystallized and their mechanisms of action are under intense scrutiny. Studies of vitamin E metabolism suggest that xenobiotic metabolism may not only regulate vitamin E concentrations, but that vitamin E may regulate xenobiotic clearance pathways.

SUMMARY:

Advances in our understanding of vitamin E nutrition suggest that vitamin E is a potent molecule that is closely regulated such that alpha-tocopherol is at the appropriate tissue concentrations necessary for some as yet to be described functions.

PMID:: 15711217; [PubMed - indexed for MEDLINE]

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Cited by 2 PubMed Central articles

Factors associated with serum retinol, alpha-tocopherol, carotenoids, and selenium in Hispanics with problems of HIV, chronic hepatitis C, and drug use. [J Public Health Policy. 2009]
Factors associated with serum retinol, alpha-tocopherol, carotenoids, and selenium in Hispanics with problems of HIV, chronic hepatitis C, and drug use.
Forrester JE, Wang XD, Knox TA, Borek CG, Tang AM, Johnson EJ. J Public Health Policy. 2009 Sep; 30(3):285-99.
Genome wide responses of murine lungs to dietary alpha-tocopherol. [Free Radic Res. 2007]
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Vitamin E regulation.

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Abstract

PURPOSE OF REVIEW:

RECENT FINDINGS:

SUMMARY:

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