CMAJ. 2005 Feb 15;172(4):509-15.

Diagnosis and management of pertussis.

Tozzi AE, Celentano LP, Ciofi degli Atti ML, Salmaso S.

Source

Epidemiology Unit, Bambino Gesù Hospital, Rome, Italy. alberto.tozzi@opbg.net

Abstract

Pertussis is increasing in frequency among children too young to be vaccinated and among adolescents and adults. This increase is due mainly to waning immunity among vaccinated individuals, who become susceptible during adolescence and adulthood and maintain the circulation of Bordetella pertussis. Infants are at highest risk of severe illness requiring hospital admission, complications and death. The clinical presentation in adolescents, adults and vaccinated individuals may be atypical, with paroxysmal cough of short duration or simply a persistent cough. Culture and polymerase chain reaction may be used to identify B. pertussis infection, but their sensitivity is high only in the early phase of the disease. Serologic tests are not standardized for the diagnosis of pertussis, and their clinical application is limited. Erythromycin is still considered in some countries to be the "gold standard" for therapy and prophylaxis; however, azithromycin and clarithromycin seem equally efficacious and are associated with fewer side effects.

PMID:: 15710944; [PubMed - indexed for MEDLINE]
PMCID:: PMC548414

Free PMC Article

Images from this publication.See all images (1) Free text

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Molecular Biology Databases

ERYTHROMYCIN - HSDB

Supplemental Content

Save items

Related citations in PubMed

Review [Action to be taken when facing one or more cases of whooping-cough]. [Arch Pediatr. 2005]
Review [Action to be taken when facing one or more cases of whooping-cough].
Floret D, Bonmarin I, Deutsch P, Gaudelus J, Grimprel E, Guérin N, Guiso N, Morer I. Arch Pediatr. 2005 Aug; 12(8):1281-91.
Review Antibiotics for whooping cough (pertussis). [Cochrane Database Syst Rev. 2005]
Review Antibiotics for whooping cough (pertussis).
Altunaiji S, Kukuruzovic R, Curtis N, Massie J. Cochrane Database Syst Rev. 2005 Jan 25; (1):CD004404. Epub 2005 Jan 25.
Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis. [Pediatrics. 2004]
Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis.
Langley JM, Halperin SA, Boucher FD, Smith B, Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC). Pediatrics. 2004 Jul; 114(1):e96-101.
Review Antibiotics for whooping cough (pertussis). [Cochrane Database Syst Rev. 2007]
Review Antibiotics for whooping cough (pertussis).
Altunaiji S, Kukuruzovic R, Curtis N, Massie J. Cochrane Database Syst Rev. 2007 Jul 18; (3):CD004404. Epub 2007 Jul 18.
[Whooping cough: biological diagnosis]. [Arch Pediatr. 2003]
[Whooping cough: biological diagnosis].
Guiso N. Arch Pediatr. 2003 Oct; 10(10):928-31.

See reviews... See all...

Cited by 4 PubMed Central articles

Enzyme-linked immunospot assay detection of mumps-specific antibody-secreting B cells as an alternative method of laboratory diagnosis. [Clin Vaccine Immunol. 2011]
Enzyme-linked immunospot assay detection of mumps-specific antibody-secreting B cells as an alternative method of laboratory diagnosis.
Latner DR, McGrew M, Williams N, Lowe L, Werman R, Warnock E, Gallagher K, Doyle P, Smole S, Lett S, et al. Clin Vaccine Immunol. 2011 Jan; 18(1):35-42. Epub 2010 Nov 3.
Seroprevalence of pertussis among Danish patients with cough of unknown etiology. [Clin Vaccine Immunol. 2010]
Seroprevalence of pertussis among Danish patients with cough of unknown etiology.
Dalby T, Harboe ZB, Krogfelt KA. Clin Vaccine Immunol. 2010 Dec; 17(12):2016-23. Epub 2010 Oct 6.
Estimating the role of casual contact from the community in transmission of Bordetella pertussis to young infants. [Emerg Themes Epidemiol. 2007]
Estimating the role of casual contact from the community in transmission of Bordetella pertussis to young infants.
Wendelboe AM, Hudgens MG, Poole C, Van Rie A. Emerg Themes Epidemiol. 2007 Oct 19; 4:15. Epub 2007 Oct 19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Diagnosis and management of pertussis.
Diagnosis and management of pertussis.
CMAJ. 2005 Feb 15 ;172(4):509-15.

PubMed
Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibuli...
Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration.
Proc Natl Acad Sci U S A. 2005 Feb 22 ;102(8):2946-51. Epub 2005 Feb 14 .

PubMed
Uncovering transcriptional regulation of metabolism by using metabolic network t...
Uncovering transcriptional regulation of metabolism by using metabolic network topology.
Proc Natl Acad Sci U S A. 2005 Feb 22 ;102(8):2685-9. Epub 2005 Feb 14 .

PubMed
Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.
Genetic basis of variation in adenoma multiplicity in ApcMin/+ Mom1S mice.
Proc Natl Acad Sci U S A. 2005 Feb 22 ;102(8):2868-73. Epub 2005 Feb 14 .

PubMed
Adult onset metachromatic leukodystrophy without electroclinical peripheral nerv...
Adult onset metachromatic leukodystrophy without electroclinical peripheral nervous system involvement: a new mutation in the ARSA gene.
Arch Neurol. 2005 Feb ;62(2):309-13.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: