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Cell. 2005 Feb 11;120(3):292-3.

Glial control of synaptogenesis.

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  • 1Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.


Though all communication between neurons occurs through synapses, we know surprisingly little about the mechanisms inducing their formation. In this issue of Cell, Barres and colleagues (Christopherson et al., 2005) demonstrate that glial-derived thrombospondins and additional soluble glial-secreted factors regulate synapse assembly and functional maturation.

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