Org Lett. 2005 Feb 17;7(4):597-600.

A new strategy for solid-phase depsipeptide synthesis using recoverable building blocks.

Albericio F, Burger K, Ruíz-Rodríguez J, Spengler J.

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Barcelona Biomedical Research Institute, Barcelona Science Park, University of Barcelona, 08028 Barcelona, Spain. albericio@pcb.ub.es

Abstract

The technique of choice for synthesis of small-scale depsipeptides is on a solid support. However, if expensive monomers have to be incorporated, solid-phase synthesis can quickly turn out to be unattractive because of its low atom economy. Herein, we describe a new type of recoverable and reuseable alpha-hydroxy acid building block for solid-phase synthesis and its application in the synthesis of a number of small cyclic depsipeptides. [structure: see text]

PMID:: 15704903; [PubMed - indexed for MEDLINE]

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