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Cell Cycle. 2005 Mar;4(3):392-6. Epub 2005 Mar 24.

E2F and signal transduction pathways.

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  • 1Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel.


The E2F family of transcription factors is most well known for its ability to regulate the expression of genes required for DNA replication and cell cycle progression. However, recent studies indicate that E2F can also regulate transcription of upstream components of signal transduction pathways. Here we discuss the effects of E2F activity on signal transduction pathways and its potential biological consequences.

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