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    J Heart Lung Transplant. 2005 Feb;24(2):222-5.

    Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopenia.

    Source

    Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.

    Abstract

    Heparin-induced thrombocytopenia (HIT) is an increasingly common clinical finding in patients presenting for cardiac transplantation. Bivalrudin, a reversible direct thrombin inhibitor, is a molecular anti-coagulant with short half-life and the potential for removal by intraoperative hemofiltration. Herein we describe the dosing and intraoperative management of bivalrudin anti-coagulation in a patient undergoing urgent cardiac transplantation in the context of recently diagnosed HIT.

    PMID:
    15701441
    [PubMed - indexed for MEDLINE]

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