Microbial production and applications of chiral hydroxyalkanoates

Guo-Qiang Chen; Qiong Wu

doi:10.1007/s00253-005-1917-2

Microbial production and applications of chiral hydroxyalkanoates

Appl Microbiol Biotechnol. 2005 Jun;67(5):592-9. doi: 10.1007/s00253-005-1917-2. Epub 2005 Feb 8.

Authors

Guo-Qiang Chen¹, Qiong Wu

Affiliation

¹ MOE Laboratory of Protein Science, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China. chengq@mail.tsinghua.edu.cn

PMID: 15700123
DOI: 10.1007/s00253-005-1917-2

Abstract

Polyhydroxyalkanoates (PHA) are a family of polyesters consisting of over 150 chiral hydroxyalkanoic acids (HA). This paper reviews the physiological functions of (R)-3-hydroxybutyric acid (3HB) and (R)-4-hydroxybutyric acid and summarizes the technologies developed to produce various HA [3HB, (R)-3-hydroxyoctanoic acid, (R)-3-hydroxydecanoic acid, etc.] and the applications of chiral HA. Their outlooks and perspectives are discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

3-Hydroxybutyric Acid / metabolism
Acyltransferases / metabolism
Bacteria / metabolism*
Caprylates / metabolism
Decanoic Acids / metabolism
Hydroxy Acids / metabolism*
Hydroxybutyrates / metabolism
Industrial Microbiology*
Stereoisomerism

Substances

Caprylates
Decanoic Acids
Hydroxy Acids
Hydroxybutyrates
4-hydroxybutyric acid
3-hydroxyoctanoic acid
Acyltransferases
poly(3-hydroxyalkanoic acid) synthase
myrmicacin
3-Hydroxybutyric Acid