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    Nat Immunol. 2005 Mar;6(3):261-70. Epub 2005 Feb 6.

    Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse.

    Gomez TS, Hamann MJ, McCarney S, Savoy DN, Lubking CM, Heldebrant MP, Labno CM, McKean DJ, McNiven MA, Burkhardt JK, Billadeau DD.

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    Department of Immunology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.

    Abstract

    Actin reorganization at the immunological synapse is required for the amplification and generation of a functional immune response. Using small interfering RNA, we show here that dynamin 2 (Dyn2), a large GTPase involved in receptor-mediated internalization, did not alter antibody-mediated T cell receptor internalization but considerably affected T cell receptor-stimulated T cell activation by regulating multiple biochemical signaling pathways and the accumulation of F-actin at the immunological synapse. Moreover, Dyn2 interacted directly with the Rho family guanine nucleotide exchange factor Vav1, and this interaction was required for T cell activation. These data identify a functionally important interaction between Dyn2 and Vav1 that regulates actin reorganization and multiple signaling pathways in T lymphocytes.

    PMID:
    15696170
    [PubMed - indexed for MEDLINE]

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