Seizure. 2005 Mar;14(2):117-22.

A systematic review of treatment of typical absence seizures in children and adolescents with ethosuximide, sodium valproate or lamotrigine.

Source

Sir James Spence Institute of Child Health, The Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. E.B.Posner@ncl.ac.uk

Abstract

PURPOSE:

To evaluate the role of ethosuximide, sodium valproate and lamotrigine in children and adolescents with typical absence seizures (AS).

METHODS:

A systematic review of randomized controlled trials that included children or adolescents with typical absence seizures who received treatment with ethosuximide, sodium valproate or lamotrigine.

RESULTS:

Four RCTs fulfilled the inclusion criteria. Due to the heterogeneity of the studies the results could not be pooled in a meta-analysis.

CONCLUSIONS:

We found no reliable evidence to inform clinical practice. The design of further trials should be pragmatic and compare one drug with another.

PMID:: 15694565; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

Supplemental Content

Related citations

Review Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents. [Cochrane Database Syst Rev. 2005]
Review Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents.
Posner EB, Mohamed K, Marson AG. Cochrane Database Syst Rev. 2005 Oct 19; (4):CD003032. Epub 2005 Oct 19.
Review Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents. [Cochrane Database Syst Rev. 2003]
Review Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents.
Posner EB, Mohamed K, Marson AG. Cochrane Database Syst Rev. 2003; (3):CD003032.
Review [Use of lamotrigine in the treatment of absence epilepsy crises]. [Rev Neurol. 2001]
Review [Use of lamotrigine in the treatment of absence epilepsy crises].
Mauri-Llerda JA, Tejero-Juste C, Iñiguez C, Morales-Asín F. Rev Neurol. 2001 Feb 1-15; 32(3):247-50.
Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. [N Engl J Med. 2010]
Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.
Glauser TA, Cnaan A, Shinnar S, Hirtz DG, Dlugos D, Masur D, Clark PO, Capparelli EV, Adamson PC, Childhood Absence Epilepsy Study Group. N Engl J Med. 2010 Mar 4; 362(9):790-9.
Use of a new antiepileptic drug or an old one as first drug for treatment of absence epilepsy. [Epilepsia. 2009]
Use of a new antiepileptic drug or an old one as first drug for treatment of absence epilepsy.
Penovich PE, Willmore LJ. Epilepsia. 2009 Sep; 50 Suppl 8:37-41.

See reviews... See all...

Cited by 2 PubMed Central articles

Treatment of childhood absence epilepsy-an evidence-based answer at last! [Epilepsy Curr. 2011]
Treatment of childhood absence epilepsy-an evidence-based answer at last!
Buchhalter J. Epilepsy Curr. 2011 Jan; 11(1):12-5.
Lamotrigine monotherapy for newly diagnosed typical absence seizures in children. [Epilepsy Res. 2008]
Lamotrigine monotherapy for newly diagnosed typical absence seizures in children.
Holmes GL, Frank LM, Sheth RD, Philbrook B, Wooten JD, Vuong A, Kerls S, Hammer AE, Messenheimer J. Epilepsy Res. 2008 Dec; 82(2-3):124-32. Epub 2008 Sep 7.

Chemical compound information

lamotrigine

MW: 256.09 g/mol

MF: C₉H₇Cl₂N₅

See 103 citations for this compound....

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A systematic review of treatment of typical absence seizures in children and ado...
A systematic review of treatment of typical absence seizures in children and adolescents with ethosuximide, sodium valproate or lamotrigine.
Seizure. 2005 Mar ;14(2):117-22.

PubMed
A genome-wide meta-analysis identifies 22 loci associated with eight hematologic...
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
Nat Genet. 2009 Nov ;41(11):1182-90. Epub 2009 Oct 11 .

PubMed
Disciplinary baptisms: a comparison of the naming stories of genetics, molecular...
Disciplinary baptisms: a comparison of the naming stories of genetics, molecular biology, genomics, and systems biology.
Hist Philos Life Sci. 2007 ;29(1):5-32.

PubMed
conserved protein [Escherichia coli str. K-12 substr. MG1655]
conserved protein [Escherichia coli str. K-12 substr. MG1655]
gi|16128398|ref|NP_414947.1|

Protein
Effects of tonsillectomy on speech and voice.
Effects of tonsillectomy on speech and voice.
J Voice. 2009 Sep ;23(5):614-8. Epub 2008 May 12 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: