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Seizure. 2005 Mar;14(2):117-22.

A systematic review of treatment of typical absence seizures in children and adolescents with ethosuximide, sodium valproate or lamotrigine.

Author information

  • 1Sir James Spence Institute of Child Health, The Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. E.B.Posner@ncl.ac.uk

Abstract

PURPOSE:

To evaluate the role of ethosuximide, sodium valproate and lamotrigine in children and adolescents with typical absence seizures (AS).

METHODS:

A systematic review of randomized controlled trials that included children or adolescents with typical absence seizures who received treatment with ethosuximide, sodium valproate or lamotrigine.

RESULTS:

Four RCTs fulfilled the inclusion criteria. Due to the heterogeneity of the studies the results could not be pooled in a meta-analysis.

CONCLUSIONS:

We found no reliable evidence to inform clinical practice. The design of further trials should be pragmatic and compare one drug with another.

PMID:
15694565
[PubMed - indexed for MEDLINE]
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