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Department of Zoology, University of Wisconsin, 250 North Mills St., Madison, Wisconsin 53706, USA. ssblair@wisc.edu
The role of the Glypican proteoglycans in Wingless signaling has been controversial. New studies show that the Glypican Dally-like can have both positive and negative effects on Wingless signaling; moreover, signaling can be regulated by removing Dally-like from the cell surface.
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