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Genome Biol. 2005;6(2):205. Epub 2005 Jan 25.

Temporal and spatial patterning of an organ by a single transcription factor.

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  • 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.

Abstract

During the formation of animal organs, a single regulatory factor can control the majority of cell-fate decisions, but the mechanisms by which this occurs are poorly understood. One such regulator, the nematode transcription factor PHA-4, functions together with various cis-regulatory elements in target genes to regulate spatial and temporal patterning during development of the pharynx.

PMID:
15693952
[PubMed - indexed for MEDLINE]
PMCID:
PMC551524
Free PMC Article
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