Mol Cell Neurosci. 2005 Feb;28(2):215-28.

Regulation of cortical dendrite development by Rap1 signaling.

Source

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Abstract

Rap1 is a small GTP-binding protein that has been implicated in intracellular signaling and cytoskeletal control. Here, we show that Rap1 is expressed in rat cortical neurons and plays a critical role in dendritic development. Inhibition of Rap1 signaling either by expressing dominant negative mutant of Rap1 or Rap1GAP in cortical neurons reduced dendritic complexity. In contrast, expression of a constitutively active mutant of Rap1 (Rap1V12) induced dendritic growth and branching. Membrane depolarization, which induces dendritic growth via calcium influx, led to a rapid activation of Rap1 via cAMP and cGMP signaling. A CREB-dependent mechanism is involved in depolarization-induced dendritic growth in cortical neurons. Rap1 function contributed to depolarization induced CREB activation, and inhibition of CREB suppressed dendritic growth induced by Rap1V12. These observations identify Rap1 as a key mediator of calcium regulation of CREB-dependent transcription and dendritic development.

PMID:: 15691704; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Calcium and cAMP signals differentially regulate cAMP-responsive element-binding protein function via a Rap1-extracellular signal-regulated kinase pathway. [J Biol Chem. 2000]
Calcium and cAMP signals differentially regulate cAMP-responsive element-binding protein function via a Rap1-extracellular signal-regulated kinase pathway.
Grewal SS, Fass DM, Yao H, Ellig CL, Goodman RH, Stork PJ. J Biol Chem. 2000 Nov 3; 275(44):34433-41.
Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription. [Neuron. 2002]
Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription.
Redmond L, Kashani AH, Ghosh A. Neuron. 2002 Jun 13; 34(6):999-1010.
IGF-I and vasoactive intestinal peptide (VIP) regulate cAMP-response element-binding protein (CREB)-dependent transcription via the mitogen-activated protein kinase (MAPK) pathway in pituitary cells: requirement of Rap1. [J Mol Endocrinol. 2005]
IGF-I and vasoactive intestinal peptide (VIP) regulate cAMP-response element-binding protein (CREB)-dependent transcription via the mitogen-activated protein kinase (MAPK) pathway in pituitary cells: requirement of Rap1.
Fernández M, Sánchez-Franco F, Palacios N, Sánchez I, Cacicedo L. J Mol Endocrinol. 2005 Jun; 34(3):699-712.
Review PACAP signaling to DREAM: a cAMP-dependent pathway that regulates cortical astrogliogenesis. [Mol Neurobiol. 2009]
Review PACAP signaling to DREAM: a cAMP-dependent pathway that regulates cortical astrogliogenesis.
Vallejo M. Mol Neurobiol. 2009 Apr; 39(2):90-100. Epub 2009 Feb 24.
Review Regulation of dendritic development by calcium signaling. [Cell Calcium. 2005]
Review Regulation of dendritic development by calcium signaling.
Redmond L, Ghosh A. Cell Calcium. 2005 May; 37(5):411-6.

See reviews... See all...

Cited by 9 PubMed Central articles

Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase. [J Neurosci. 2011]
Neuronal nitric oxide contributes to neuroplasticity-associated protein expression through cGMP, protein kinase G, and extracellular signal-regulated kinase.
Gallo EF, Iadecola C. J Neurosci. 2011 May 11; 31(19):6947-55.
Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth. [J Biol Chem. 2011]
Dual regulation of RA-RhoGAP activity by phosphatidic acid and Rap1 during neurite outgrowth.
Kurooka T, Yamamoto Y, Takai Y, Sakisaka T. J Biol Chem. 2011 Feb 25; 286(8):6832-43. Epub 2010 Dec 17.
Review Epac2-mediated dendritic spine remodeling: implications for disease. [Mol Cell Neurosci. 2011]
Review Epac2-mediated dendritic spine remodeling: implications for disease.
Penzes P, Woolfrey KM, Srivastava DP. Mol Cell Neurosci. 2011 Feb; 46(2):368-80. Epub 2010 Nov 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (GeneRIF)
Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Regulation of cortical dendrite development by Rap1 signaling.
Regulation of cortical dendrite development by Rap1 signaling.
Mol Cell Neurosci. 2005 Feb ;28(2):215-28.

PubMed
A single amino acid substitution (Met786----Val) in the steroid-binding domain o...
A single amino acid substitution (Met786----Val) in the steroid-binding domain of human androgen receptor leads to complete androgen insensitivity syndrome.
J Clin Endocrinol Metab. 1992 May ;74(5):1152-7.

PubMed
Of the renin-angiotensin system and reactive oxygen species Type 2 diabetes and ...
Of the renin-angiotensin system and reactive oxygen species Type 2 diabetes and angiotensin II inhibition.
Am J Hypertens. 2005 Jan ;18(1):121-8.

PubMed
A randomized controlled trial of stress reduction in African Americans treated f...
A randomized controlled trial of stress reduction in African Americans treated for hypertension for over one year.
Am J Hypertens. 2005 Jan ;18(1):88-98.

PubMed
Ocular manifestations of keratitis-ichthyosis-deafness (KID) syndrome.
Ocular manifestations of keratitis-ichthyosis-deafness (KID) syndrome.
Ophthalmology. 2005 Feb ;112(2):e1-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: