Nat Rev Mol Cell Biol. 2005 Jan;6(1):9-20.

Function and regulation of cullin-RING ubiquitin ligases.

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Division of Biology and Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA. petroski@caltech.edu deshaies@caltech.edu

Abstract

Cullin-RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin-RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin-RING ligases, and describe how these enzymes can be characterized by a set of general principles.

PMID:: 15688063; [PubMed - indexed for MEDLINE]

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