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Cell Res. 2005 Jan;15(1):49-51.

HGF/SF-Met signaling in tumor progression.

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  • 1Laboratory of Molecular Oncology, Van Andel Research Institute,#333 Bostwick Ave., N.E, Grand Rapids, MI 49503, USA.


Tumor progression is a multi-step process that requires a sequential selection of specific malignant phenotypes. Met activation may induce different phenotypes depending on tumor stage: inducing proliferation and angiogenesis in primary tumors, stimulating motility to form micrometastases, and regaining the proliferation phenotype to form overt metastases. To study how HGF/SF-induced proliferative phenotypes switch to the invasive phenotype is important for understanding the mechanism of tumor progression and will provide an attractive target for cancer intervention and therapy.

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