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Sleep. 2004 Dec 15;27(8):1471-5.

The month-of-birth pattern in narcolepsy is moderated by cataplexy severity and may be independent of HLA-DQB1*0602.

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  • 1University of Southern Mississippi, Hattiesburg, USA.

Abstract

OBJECTIVES:

A March peak and a September trough in the birth pattern of narcolepsy patients with clear-cut cataplexy was recently reported. The objectives of the present study were to determine whether the month-of-birth pattern would (a) vary with the presence and severity of cataplexy and (b) differ for patients positive and negative for HLA-DQB1*0602.

DESIGN:

Cross-sectional survey with data obtained from the clinical trials assessing the safety and efficacy of modafinil in the treatment of narcolepsy.

SETTING:

Sleep clinics throughout the United States.

PATIENTS:

A group of 530 narcolepsy patients diagnosed based on the International Classification of Sleep Disorders using clinical histories, nocturnal polysomnography, and Multiple Sleep Latency Tests.

INTERVENTIONS:

NA.

MEASUREMENTS AND RESULTS:

A surplus of March births and a fall-off in September births was found in narcolepsy relative to the general population. This finding was only observed when cataplexy was moderate or severe. The month-of-birth pattern was similar for HLA-DQB1*0602 positive and negative patients. A March birth and HLA-DQB1*0602 positivity were independent risk factors in a logistic regression analysis.

CONCLUSIONS:

Environmental events during development may influence narcolepsy severity or the likelihood of developing the disease.

PMID:
15683136
[PubMed - indexed for MEDLINE]
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