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Science. 2005 Mar 11;307(5715):1634-8. Epub 2005 Jan 27.

BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses.

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  • 1Department of Plant Biology, Carnegie Institution, Stanford, CA 94305, USA.

Erratum in

  • Science. 2005 Jun 17;308(5729):1743.

Abstract

Brassinosteroid (BR) homeostasis and signaling are crucial for normal growth and development of plants. BR signaling through cell-surface receptor kinases and intracellular components leads to dephosphorylation and accumulation of the nuclear protein BZR1. How BR signaling regulates gene expression, however, remains unknown. Here we show that BZR1 is a transcriptional repressor that has a previously unknown DNA binding domain and binds directly to the promoters of feedback-regulated BR biosynthetic genes. Microarray analyses identified additional potential targets of BZR1 and illustrated, together with physiological studies, that BZR1 coordinates BR homeostasis and signaling by playing dual roles in regulating BR biosynthesis and downstream growth responses.

PMID:
15681342
[PubMed - indexed for MEDLINE]
PMCID:
PMC2925132
Free PMC Article
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