Display Settings:


Send to:

Choose Destination
Cell. 2005 Jan 28;120(2):159-62.

Eating oneself and uninvited guests: autophagy-related pathways in cellular defense.

Author information

  • Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75330, USA. beth.levine@utsouthwestern.edu


The eukaryotic cell uses an evolutionarily conserved lysosomal pathway of self-digestion (autophagy) for survival when extracellular nutrients are limited. In this issue of Cell, new evidence indicates that autophagy is used to for survival when intracellular nutrients are limited by growth factor deprivation (Lum et al., 2005). Other recent studies indicate that the autophagy machinery is also used to degrade foreign microbial invaders (xenophagy).

Comment on

[PubMed - indexed for MEDLINE]
Free full text

LinkOut - more resources

Full Text Sources

Other Literature Sources

Research Materials

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk