Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int Braz J Urol. 2004 Jul-Aug;30(4):279-85; discussion 285-8.

NAT2 gene polymorphism in bladder cancer: a study from North India.

Author information

  • 1Department of Urology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India. rmittal@sgpgi.ac.in

Abstract

PURPOSE:

This study was conducted to examine: 1) whether the NAT2 genotypes are risk factors for bladder cancer, 2) to study possible association of tobacco usage with NAT2 genotype of these patients.

MATERIALS AND METHODS:

This case control study was undertaken over a period of 19 months and included 101 bladder cancer patients and 110 controls. The NAT2 genotypes were identified by PCR-RFLP method in peripheral blood DNA samples. Genotypes frequencies and the association of the genotypes among patients and controls group were assessed by Chi2 test and Fisher exact test.

RESULTS:

The NAT2 fast acetylator genotype frequency of slow or fast acetylator genotypes was not significant in bladder cancer patients alone (OR = 1.18, 95% CI: 0.69 - 2.03, p value = 0.583) or combination with tobacco users (OR = 0.84, 95% CI: 0.328 - 2.125, p value = 0.813) when compared with controls.

CONCLUSION:

These data demonstrate that the NAT2 fast or slow acetylators genotype did not associated with the risk of developing bladder cancer in North Indian population when compared with controls.

PMID:
15679955
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for International Braz J Urol
    Loading ...
    Write to the Help Desk