Two new hepatoprotective stilbene glycosides from Acer mono leaves

Hyekyung Yang; Sang Hyun Sung; Young Choong Kim

doi:10.1021/np0497907

Two new hepatoprotective stilbene glycosides from Acer mono leaves

J Nat Prod. 2005 Jan;68(1):101-3. doi: 10.1021/np0497907.

Authors

Hyekyung Yang¹, Sang Hyun Sung, Young Choong Kim

Affiliation

¹ College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Sillim-Dong, Gwanak-Gu, Seoul 151-742, Korea.

PMID: 15679328
DOI: 10.1021/np0497907

Abstract

Two new stilbene glycosides, 5-O-methyl-(E)-resveratrol 3-O-beta-d-glucopyranoside (1) and 5-O-methyl-(E)-resveratrol 3-O-beta-D-apiofuranosyl-(1-->6)-beta-d-glucopyranoside (2), were isolated from the leaves of Acer mono, along with seven known compounds. Among these compounds, 1, 2, and quercetin (3) showed significant hepatoprotective activities against H(2)O(2)-induced toxicity in primary cultures of rat hepatocytes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acer / chemistry*
Animals
Glucosides / chemistry
Glucosides / isolation & purification*
Glucosides / pharmacology
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology
Hepatocytes / drug effects
Hydrogen Peroxide / toxicity
Korea
Male
Plant Leaves / chemistry
Plants, Medicinal / chemistry*
Quercetin / pharmacology
Rats
Rats, Wistar
Stilbenes / chemistry
Stilbenes / isolation & purification*
Stilbenes / pharmacology

Substances

5-O-methyl-(E)-resveratrol 3-O-beta-D-glucopyranoside
5-O-methyl-(E)-resveratrol-3-O-beta-D-apiofuranosyl-(1-6)-beta-D-glucopyranoside
Glucosides
Glycosides
Stilbenes
Quercetin
Hydrogen Peroxide