In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia

Youn-Chul Kim; Hyuncheol Oh; Beom Seok Kim; Tai-Hyun Kang; Eun-Kyoung Ko; Yu Mi Han; Bo Yeon Kim; Jong Seog Ahn

doi:10.1055/s-2005-837759

In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia

Planta Med. 2005 Jan;71(1):87-9. doi: 10.1055/s-2005-837759.

Authors

Youn-Chul Kim¹, Hyuncheol Oh, Beom Seok Kim, Tai-Hyun Kang, Eun-Kyoung Ko, Yu Mi Han, Bo Yeon Kim, Jong Seog Ahn

Affiliation

¹ Phytofermentation Research Center and College of Pharmacy, Wonkwang University, Iksan, South Korea.

PMID: 15678382
DOI: 10.1055/s-2005-837759

Abstract

Protein tyrosine phosphatase 1B plays a major role in the negative regulation of insulin signaling, and this establishes protein tyrosine phosphatase 1B as an attractive therapeutic target for diabetes. Bioassay-guided fractionation of the EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin (1) and bakuchiol (2), along with inactive corylin. Compounds 1 and 2 inhibited PTP1B activity in a dose-dependent manner, displaying IC50 values of 9.4 +/- 0.5 microM and 20.8 +/- 1.9 microM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dose-Response Relationship, Drug
Enzyme Inhibitors / administration & dosage
Enzyme Inhibitors / pharmacology*
Enzyme Inhibitors / therapeutic use
Humans
Phenols / administration & dosage
Phenols / pharmacology
Phenols / therapeutic use
Phytotherapy*
Plant Extracts / administration & dosage
Plant Extracts / pharmacology*
Plant Extracts / therapeutic use
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases / antagonists & inhibitors*
Psoralea*
Seeds

Substances

Enzyme Inhibitors
Phenols
Plant Extracts
PTPN1 protein, human
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases