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    J Clin Pathol. 2005 Feb;58(2):214-6.

    Eruptive tufted angiomas in a patient with Crohn's disease.

    Al-Za'abi AM, Ghazarian D, Greenberg GR, Shaw JC.

    Department of Pathology, University of Toronto, Toronto M5T 2S8, Canada.

    Angioblastoma is a rare, benign vascular tumour composed of undifferentiated mesenchymal cells with a tendency to form lumina. This entity was first described by Nakagawa in 1949 as angioblastoma, and Wilson Jones was the first to use the term "tufted angioma" in 1976. Tufted angiomas usually occur in infancy and spread slowly. This report describes lesions from the right side of the forehead, forearms, and thighs of a 24 year old man with a four year history of Crohn's disease, who was receiving infliximab in addition to long standing azathioprine and ciprofloxacillin. He developed numerous small itchy erythematous vascular appearing papules, which on histological examination resembled tufted angiomas, showing the classic "cannon ball" appearance. The lesions regressed within three months. This case may represent an eruptive acquired tufted angioma in which immunosuppression or drug induced modification of angiogenesis played a role in its development and regression. One previous case of eruptive tufted angioma has been reported in an immunosuppressed patient.

    PMID: 15677546 [PubMed - indexed for MEDLINE]

    PMCID: PMC1770572

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    Patient drug information

    • Azathioprine (Azasan®, Imuran®)

      Azathioprine is used with other medications to prevent rejection of kidney transplants. It is also used to treat severe rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain and swellin...

    • Infliximab Injection (Remicade®)

      Infliximab is used to relieve the symptoms of certain autoimmune disorders (conditions in which the immune system attacks healthy parts of the body and causes pain, swelling, and damage) including: rheumatoid arthritis...