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J Altern Complement Med. 2004 Dec;10(6):1015-8.

Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study.

Author information

  • 1Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, UK. r.bundy@reading.ac.uk

Abstract

OBJECTIVES:

To assess the effects of turmeric (Curcuma longa) extract on irritable bowel syndrome (IBS) symptomology in otherwise healthy adults.

DESIGN:

Partially blinded, randomized, two-dose, pilot study.

SUBJECTS:

Five hundred (500) volunteers were screened for IBS using the Rome II criteria. Two hundred and seven (207) suitable volunteers were randomized.

INTERVENTIONS:

One or two tablets of a standardized turmeric extract taken daily for 8 weeks.

OUTCOMES MEASURES:

IBS prevalence, symptom-related quality of life (IBSQOL) and self-reported effectiveness.

RESULTS:

IBS prevalence decreased significantly in both groups between screening and baseline (41% and 57%), with a further significant drop of 53% and 60% between baseline and after treatment, in the one- and two-tablet groups respectively (p < 0.001). A post-study analysis revealed abdominal pain/discomfort score reduced significantly by 22% and 25% in the one- and two-tablet group respectively, the difference tending toward significance (p = 0.071). There were significant improvements in all bar one of the IBSQOL scales of between 5% and 36% in both groups, approximately two thirds of all subjects reported an improvement in symptoms after treatment, and there was a favorable shift in self-reported bowel pattern. There were no significant differences between groups.

CONCLUSIONS:

Turmeric may help reduce IBS symptomology. Placebo controlled trials are now warranted to confirm these findings.

PMID:
15673996
[PubMed - indexed for MEDLINE]
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