J Acquir Immune Defic Syndr. 2005 Feb 1;38(2):124-34.

Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV.

Van Rompay KK, Abel K, Lawson JR, Singh RP, Schmidt KA, Evans T, Earl P, Harvey D, Franchini G, Tartaglia J, Montefiori D, Hattangadi S, Moss B, Marthas ML.

Source

California National Primate Research Center, University of California at Davis, Davis, CA 95616, USA.

Abstract

An infant macaque model was developed to test pediatric vaccine candidates aimed at reducing HIV transmission through breast-feeding. Infant macaques were given multiple immunizations during the first 3 weeks of life with recombinant poxvirus vaccines expressing simian immunodeficiency virus (SIV) structural proteins Gag, Pol, and Env (ALVAC-SIV or modified vaccinia virus Ankara [MVA]-SIV). After repeated daily oral inoculations with virulent SIVmac251 at 4 weeks of age, significantly fewer ALVAC-SIV-immunized infants were infected compared with unimmunized infants. Monkeys not infected after oral challenge in infancy were rechallenged at 16 months of age or older by repeated weekly oral SIV exposure; unimmunized animals were infected after fewer SIV exposures than were animals vaccinated with ALVAC-SIV or MVA-SIV. When infected, ALVAC-SIV- and MVA-SIV-vaccinated animals also had reduced viremia compared with unimmunized animals. The results of these investigations suggest that immunization of human infants with poxvirus-based HIV vaccine candidates may offer protection against early and late HIV infection through breastfeeding.

PMID:: 15671796; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

HIV InSite

Supplemental Content

Related citations

Comparative efficacy of recombinant modified vaccinia virus Ankara expressing simian immunodeficiency virus (SIV) Gag-Pol and/or Env in macaques challenged with pathogenic SIV. [J Virol. 2000]
Comparative efficacy of recombinant modified vaccinia virus Ankara expressing simian immunodeficiency virus (SIV) Gag-Pol and/or Env in macaques challenged with pathogenic SIV.
Ourmanov I, Brown CR, Moss B, Carroll M, Wyatt L, Pletneva L, Goldstein S, Venzon D, Hirsch VM. J Virol. 2000 Mar; 74(6):2740-51.
Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals. [Virol J. 2005]
Simian immunodeficiency virus (SIV) envelope quasispecies transmission and evolution in infant rhesus macaques after oral challenge with uncloned SIVmac251: increased diversity is associated with neutralizing antibodies and improved survival in previously immunized animals.
Greenier JL, Van Rompay KK, Montefiori D, Earl P, Moss B, Marthas ML. Virol J. 2005 Feb 14; 2:11. Epub 2005 Feb 14.
Immunization of newborn rhesus macaques with simian immunodeficiency virus (SIV) vaccines prolongs survival after oral challenge with virulent SIVmac251. [J Virol. 2003]
Immunization of newborn rhesus macaques with simian immunodeficiency virus (SIV) vaccines prolongs survival after oral challenge with virulent SIVmac251.
Van Rompay KK, Greenier JL, Cole KS, Earl P, Moss B, Steckbeck JD, Pahar B, Rourke T, Montelaro RC, Canfield DR, et al. J Virol. 2003 Jan; 77(1):179-90.
Review Cytotoxic T lymphocytes specific for the simian immunodeficiency virus. [Immunol Rev. 1999]
Review Cytotoxic T lymphocytes specific for the simian immunodeficiency virus.
Letvin NL, Schmitz JE, Jordan HL, Seth A, Hirsch VM, Reimann KA, Kuroda MJ. Immunol Rev. 1999 Aug; 170:127-34.
Review SIV vaccines: current status. The role of the SIV-macaque model in AIDS research. [Vaccine. 1991]
Review SIV vaccines: current status. The role of the SIV-macaque model in AIDS research.
Gardner M. Vaccine. 1991 Nov; 9(11):787-91.

See reviews... See all...

Cited by 17 PubMed Central articles

Immune-based approaches to the prevention of mother-to-child transmission of HIV-1: active and passive immunization. [Clin Perinatol. 2010]
Immune-based approaches to the prevention of mother-to-child transmission of HIV-1: active and passive immunization.
Lohman-Payne B, Slyker J, Rowland-Jones SL. Clin Perinatol. 2010 Dec; 37(4):787-805, ix.
Review HIV vaccines: lessons learned and the way forward. [Curr Opin HIV AIDS. 2010]
Review HIV vaccines: lessons learned and the way forward.
Kim JH, Rerks-Ngarm S, Excler JL, Michael NL. Curr Opin HIV AIDS. 2010 Sep; 5(5):428-34.
Safety and immunogenicity of novel recombinant BCG and modified vaccinia virus Ankara vaccines in neonate rhesus macaques. [J Virol. 2010]
Safety and immunogenicity of novel recombinant BCG and modified vaccinia virus Ankara vaccines in neonate rhesus macaques.
Rosario M, Fulkerson J, Soneji S, Parker J, Im EJ, Borthwick N, Bridgeman A, Bourne C, Joseph J, Sadoff JC, et al. J Virol. 2010 Aug; 84(15):7815-21. Epub 2010 May 19.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in ...
Attenuated poxvirus-based simian immunodeficiency virus (SIV) vaccines given in infancy partially protect infant and juvenile macaques against repeated oral challenge with virulent SIV.
J Acquir Immune Defic Syndr. 2005 Feb 1 ;38(2):124-34.

PubMed
Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancrea...
Increased expression of the heterogeneous nuclear ribonucleoprotein K in pancreatic cancer and its association with the mutant p53.
Int J Cancer. 2010 Jan 15 ;126(2):395-404.

PubMed
An isotopically coded CID-cleavable biotinylated cross-linker for structural pro...
An isotopically coded CID-cleavable biotinylated cross-linker for structural proteomics.
Mol Cell Proteomics. 2011 Feb ;10(2):M110.001420. Epub 2010 Jul 9 .

PubMed
In vitro reconstruction of an autologous, watertight, and resistant vesical equi...
In vitro reconstruction of an autologous, watertight, and resistant vesical equivalent.
Tissue Eng Part A. 2010 May ;16(5):1539-48.

PubMed
ICC-CLASS: isotopically-coded cleavable crosslinking analysis software suite.
ICC-CLASS: isotopically-coded cleavable crosslinking analysis software suite.
BMC Bioinformatics. 2010 Jan 28 ;11:64.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: