Am J Physiol. 1992 Apr;262(4 Pt 2):R684-8.

Skeletal muscle composition in dietary obesity-susceptible and dietary obesity-resistant rats.

Abou Mrad J, Yakubu F, Lin D, Peters JC, Atkinson JB, Hill JO.

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Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232.

Abstract

The intent of this study was to determine whether a relationship exists between susceptibility to high-fat diet (HFD)-induced obesity and skeletal muscle fiber type. Forty-four adult male Wistar rats were given ad libitum access to a HFD (60% of calories from fat) for 4 wk. Rats were then grouped into quartiles for total weight gain, and the top-quartile [obesity prone (OP)] rats were compared with the bottom-quartile [obesity resistant (OR)] rats. OP rats gained 1.5 times as much weight as OR rats. OR rats had a significantly higher proportion of type I muscle fibers in the medial head of the gastrocnemius muscle than OP rats both before (determined from a muscle biopsy) and after the HFD feeding period. A greater proportion of type I fibers may be associated with a greater capacity for fat oxidation, which would favor resistance to body fat accumulation. Preexisting differences in muscle fiber composition may play a role in determining susceptibility to dietary obesity.

PMID:: 1566936; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, P.H.S.

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DK-38088/DK/NIDDK NIH HHS/United States

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