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Neurology. 2005 Jan 25;64(2):377-9.

An African American family with early-onset Alzheimer disease and an APP (T714I) mutation.

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  • 1Department of Neurology,Harbor-UCLA Medical Center, Torrance, USA.


The occurrence of an APP T174I mutation is described in a large American family of African descent with Alzheimer disease. The clinical characteristics were an unusually early onset of disease (early 30s), similar to a previously reported age at onset of this mutation in an Austrian family. Distinct from that family, seizures and myoclonus were prominent features of the disease in this kindred.

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